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Cruises Departing From San Diego

San Diego is a city offering a little for everyone. Tons of beaches line San Diego's coastline, ranging from the surfer's beach to the family beach to the private romantic beaches hidden away from the crowds. Attractions like Sea World and the world famous San Diego Zoo are a big reason San Diego is a great family destination. And for those who are just here to get away for the weekend and have a good time, San Diego offers an unbelievable nightlife with outrageous nightclubs, live concerts, professional sports, theatrical performances and much more.

San Diego Departures

168 Cruises Found

4-night Baja Mexico Cruise 11/5/2020

PORTS: San Diego | Catalina Island | Ensenada | San Diego |

5-night Baja Mexico from San Diego Cruise 11/9/2020

PORTS: San Diego | Cabo San Lucas | Cabo San Lucas | San Diego |

15-night Panama Canal Eastbound Cruise 11/13/2020

PORTS: San Diego | Cabo San Lucas | Puerto Vallarta | Puerto Quetzal | Puntarenas | Panama Canal | Colon (Panama) | Cartagena (Colombia) | Ft. Lauderdale |

from $1319

5-night Baja Mexico from San Diego Cruise 11/14/2020

PORTS: San Diego | Cabo San Lucas | Cabo San Lucas | San Diego |

4-night Baja Mexico Cruise 11/19/2020

PORTS: San Diego | Catalina Island | Ensenada | San Diego |

5-night Baja Mexico from San Diego Cruise 11/23/2020

PORTS: San Diego | Cabo San Lucas | Cabo San Lucas | San Diego |

15-night Hawaii from San Diego Cruise 11/28/2020

PORTS: San Diego | Maui | Honolulu | Kauai | Kailua-Kona | Hilo | Ensenada | San Diego |

5-night Baja Mexico from San Diego Cruise 12/13/2020

PORTS: San Diego | Cabo San Lucas | Cabo San Lucas | San Diego |

from $369

3-night Baja Mexico from San Diego Cruise 12/18/2020

PORTS: San Diego | Ensenada | San Diego |

from $279

7-night Mexican Riviera Holiday Cruise 12/19/2020

PORTS: San Diego | Puerto Vallarta | Mazatlan | Cabo San Lucas | San Diego |

from $1099

14-night Panama Canal Holiday Cruise 12/19/2020

PORTS: San Diego | Puerto Vallarta | Huatulco | Puerto Caldera | Fuerte Amador | Fuerte Amador | Panama Canal | Cartagena (Colombia) | Ft. Lauderdale |

from $1969

5-night Baja Mexico from San Diego Cruise 12/21/2020

PORTS: San Diego | Cabo San Lucas | Cabo San Lucas | San Diego |

from $639

5-night Baja Mexico from San Diego Cruise 12/26/2020

PORTS: San Diego | Cabo San Lucas | Cabo San Lucas | San Diego |

from $669

View All Cruises Departing from San Diego