CRUISES

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Cruises Departing From St. Louis

St. Louis's "gateway to the west", the Gateway Arch, is a nationally recognized site as it stands over 630 feet above the Mississippi River. Although the arch is a great site, visit some other St. Louis attractions including: historic landmarks, museums, sightseeing, shopping, and accommodations to fit every budget. St. Louis has attractions and activities for a family on vacation, someone visiting for business, or a couple searching for romance. Boating tours, museums, historic sites such as the village where Daniel Boon lived, shopping, fine dinging, and educational attractions are all within minutes from anywhere in the city. St. Louis offers culture, sophistication, old world charm, and fantastic architecture.

St. Louis Departures

19 Cruises Found

7-night Upper Mississippi River Cruise 7/21/2021

PORTS: St. Louis | Cruise Starts (Embarkation) | Alton | Hannibal | Fort Madison | Davenport | Dubuque | La Crosse | Red Wing | Red Wing | Cruise Ends (Debarkation) | St. Paul |

from $3875

7-night Upper Mississippi River Cruise 8/4/2021

PORTS: St. Louis | Cruise Starts (Embarkation) | Alton | Hannibal | Fort Madison | Davenport | Dubuque | La Crosse | Red Wing | Red Wing | Cruise Ends (Debarkation) | St. Paul |

from $3875

10-night Ohio River Cruise 8/10/2021

PORTS: St. Louis | St. Louis | Cape Girardeau | Paducah | Henderson | Louisville | Louisville | Cincinnati | Maysville | Marietta | Pittsburgh |

from $5120

10-night Ohio River Cruise 8/30/2021

PORTS: St. Louis | St. Louis | Cape Girardeau | Paducah | Henderson | Louisville | Louisville | Cincinnati | Maysville | Marietta | Pittsburgh |

from $5420

7-night Upper Mississippi River Cruise 9/4/2021

PORTS: St. Louis | Cruise Starts (Embarkation) | Alton | Hannibal | Fort Madison | Davenport | Dubuque | La Crosse | Red Wing | Red Wing | Cruise Ends (Debarkation) | St. Paul |

from $3875

7-night Upper Mississippi River Cruise 9/18/2021

PORTS: St. Louis | Cruise Starts (Embarkation) | Alton | Hannibal | Fort Madison | Davenport | Dubuque | La Crosse | Red Wing | Red Wing | Cruise Ends (Debarkation) | St. Paul |

from $3875

10-night Ohio River Cruise 9/19/2021

PORTS: St. Louis | St. Louis | Cape Girardeau | Paducah | Henderson | Louisville | Louisville | Cincinnati | Maysville | Marietta | Pittsburgh |

from $5420

7-night Upper Mississippi River Cruise 10/2/2021

PORTS: St. Louis | Cruise Starts (Embarkation) | Alton | Hannibal | Fort Madison | Davenport | Dubuque | La Crosse | Red Wing | Red Wing | Cruise Ends (Debarkation) | St. Paul |

from $3875

10-night Mississippi River Gateway Cruise 10/9/2021

PORTS: St. Louis | St. Louis | Ohio River | Paducah | New Madrid | Memphis | Mississippi River Cruising | Vicksburg | Natchez | Baton Rouge | New Orleans |

from $5660

7-night Upper Mississippi River Cruise 10/16/2021

PORTS: St. Louis | Cruise Starts (Embarkation) | Alton | Hannibal | Fort Madison | Davenport | Dubuque | La Crosse | Red Wing | Red Wing | Cruise Ends (Debarkation) | St. Paul |

from $3875

7-night Upper Mississippi River Cruise 8/3/2022

PORTS: St. Louis | Cruise Starts (Embarkation) | Alton | Hannibal | Fort Madison | Davenport | Dubuque | La Crosse | Red Wing | Red Wing | Cruise Ends (Debarkation) | St. Paul |

from $3875

10-night Ohio River Cruise 8/6/2022

PORTS: St. Louis | St. Louis | Cape Girardeau | Paducah | Henderson | Louisville | Louisville | Cincinnati | Maysville | Marietta | Pittsburgh |

from $5420

7-night America's Heartland River Cruise 8/27/2022

PORTS: St. Louis | Hannibal | Burlington | Quad Cities, Iowa | Dubuque | La Crosse | Red Wing | St. Paul |

View All Cruises Departing from St. Louis